Considerations and Treatments of Glioblastomas - 1454 Words

Malignant gliomas are the most common type of primary malignant brain tumor, and glioblastoma accounts for 82% of cases of malignant glioma. Glioblastomas arise from glial precursor cells and are characterized histologically by considerable cellularity, mitotic activity, vascular proliferation, and necrosis. They are highly invasive, infiltrating surrounding brain tissues, yet they are typically confined to the central nervous system and do not metastasize.1 From a molecular standpoint, malignant glioblastomas are heterogeneous tumors, and genome studies have demonstrated four transcriptional subclasses. These four classes display features of distinct cell types: classical, mesenchymal, proneural, and neural.1 Patients with glioblastoma experience a wide variety of complications from both the disease and drug therapies. Current standard therapies for glioblastoma are maximal safe surgical resection followed by temozolomide and radiotherapy. With these therapies the median pati ent survival is less than 2 years due to common tumor recurrence.2 However, new therapies such as targeted vascular endothelial growth factor inhibitors, carmustine wafers, and gene therapies are promising in prolonging survival and delaying progression of the disease. Patients with glioblastoma experience clinical complications of the malignancy including thromboembolic events, seizures, fluctuations in neurologic symptoms, and visual field defects, in addition to adverse effects fromShow MoreRelatedEuthanasi An Ethical And Logical Option952 Words   |  4 Pageswrong. Euthanasia is currently legal in five states, those states are New Mexico, Oregon, Montana, Washington and Vermont. Last year, Oregon successfully set an example of assisted suicide. Brittany Maynard, a 29 year old woman suffering from IV glioblastoma multiforme, a form of terminal brain cancer, successfully and peacefully ended her life after moving from San Francisco to Oregon, to take advantage of the state’s Death with Dignity Act. Her death made national headlines, making her a mascot toRead MoreWhat are Brain Tumors?1342 Words   |  5 Pagesvision, balance, hearing, reflexes and coordination. A difficulty in any of these areas will give a clue about what part of your brain is affected by a tumour. Magnetic Resonance Imaging: The test is conducted to help diagnose, evaluate and plan treatment forbrain tumours. In some cases, a dye may be injected through a vein before conducting the MRI. Different types of MRI scans include functional MRI, perfusion MRI,and magnetic resonance spectroscopy. 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Terminal is defined as treatment would be not provide a cure, be frugal to pursue, and only prolong suffering. The individual must be under the care of a physician. The request is completely voluntary and the intent of obtaining the medication is to end life through self administrationRead MoreA Student Questions : Take Home Exam1786 Words   |  8 Pagescould be a powerful approach for developing safe and effective cancer therapeutics (Dai et al 2016). Chemotherapy and radiation have been used for treatment of cancer since long time but many of the cancer remain refractory and developed resistant towards this treatment. Now, scientists are being busy in harnessing immune system and lymphocytes for treatment of cancer and many evidence shows the overwhelming efficacy of these cells in controlling and eradication of cancer (Almasbak, Aarvak, VemuriRead MoreEuthanasia Is The Act Or Practice?1924 Words   |  8 Pagesdecide to take advantage of Oregon Death with Dignity Law which allows residents with terminal illnesses to take their own life with lethal drugs provided by a doctor. Brittany Maynard whom is diagnoses with brain cancer or more specifically stage 4 glioblastoma and was told that she has 6 month to live. The woman pledged to end her own life under Oregon’s Death with Dignity Law. She died in her own home due to the lethal dose of Barbiturates that is prescribed by her doctor. She posted a goodbye letter